Uncoating : Uncoating occurs simultaneously with or rapidly after penetration. Hence, this stage is difficult to be studied and remains a relatively poorly understood stage of the replication cycle.
Uncoating in general refers
o the events that expose the viral genome to the host cellular machinery and sets the stage for the viral genome to express its functions required for the replication.
This stage occurs simultaneously with or rapidly after penetration. In order to express the viral genome to the cell organelles, it is necessary that the virion coat
e removed partially or completely. Therefore, once virions are in the cytoplasm, they are generally uncoated to some extent by a variety of processes, including simple dissociation and/or enzyme-mediated partial degradation of the particles, to release the viral geno
me as a naked nucleic acid or as a nucleoprotein complex.
The steps involved in the process of disintegration of the protein coat or capsid to release its genome into the cell is called as uncoating. Uncoating may be achieved by the complete or partial removal of the capsid.
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